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Objective:To explore the prevention and control strategies and effects of COVID-19 in People's Hospital of Tongchuan so as to provide evidence for prevention and control of COVID-19 in Tongchuan.Methods:Themeasures taken by People's Hospital of Tongchuan from the aspects of sound organization, new coronavirus knowledge training, prevention of nosocomial infection, establishment of elite medical team, scientific and precise treatment and internet applicationas well as medical treatment were reviewed. Results:Between 23 January 2020 and 15 April 2020, the hospital had received a total of 6 patients with confirmed COVID-19, among which 3 patients have been discharged. More than 31,000 persons were given pre-examination triage, 2,605 persons were treated for fever at clinics, 596 persons were under isolation and observation, and 184 persons had nucleic acid test, so as to achieve the requirements of no missed diagnosis, no death and no infection goal, which were prioritized by the national, provincial and municipal health inspection teams.Conclusion:The effective prevention and control strategies against COVID-19 in People’s Hospital of Tongchuan have significantly achieved the "three zeros" goal namely zero infection, zero transmission and zero death.People's Hospital of Tongchuan, founded in 1949, is a comprehensive level-III first-class hospital. It has two hospitals located in the north and the south, with 1,700 beds and 2,044 employees. It is the first designated hospital for treatment of COVID-19 [1]in the province.
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Background/Aim: Percutaneous thermal ablation combined with transarterial chemoembolization (TACE) becomes a treatment option for unresectable hepatocellular carcinoma (HCC). This study aims to investigate the safety and feasibility of percutaneous thermal ablation combined with simultaneous TACE for patients with HCC ≤ 5 cm. Materials and Methods: From June 2010 to February 2017, a total of 280 patients with HCC ≤ 5 cm who underwent percutaneous thermal ablation combined with simultaneous TACE were included in our study. Their clinical data were collected and analyzed. Results: Major complications occurred in five cases (1.8%). The complete necrosis rate was 91.9%. The median overall survival (OS) was 66.5 months (95% confidence interval [CI] = 57.7–75.2). The OS rates in 1-, 3-, 5-, and 7-year were 96.7%, 76.0%, 59.7%, and 31.1%, respectively. Tumor size (hazard ratio = 1.826; 95% CI = 1.131–2.947; P = 0.014) was considered as independent prognostic factors of long-term survival. Conclusion: Percutaneous thermal ablation combined with simultaneous TACE is a safe and effective treatment for HCC ≤ 5 cm.
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OBJECTIVES: The transoral atlantoaxial reduction plate system treats irreducible atlantoaxial dislocation from transoral atlantoaxial reduction plate-I to transoral atlantoaxial reduction plate-III. However, this system has demonstrated problems associated with screw loosening, atlantoaxial fixation and concealed or manifest neurovascular injuries. This study sought to design a set of individualized templates to improve the accuracy of anterior C2 screw placement in the transoral atlantoaxial reduction plate-IV procedure. METHODS: A set of individualized templates was designed according to thin-slice computed tomography data obtained from 10 human cadavers. The templates contained cubic modules and drill guides to facilitate transoral atlantoaxial reduction plate positioning and anterior C2 screw placement. We performed 2 stages of cadaveric experiments with 2 cadavers in stage one and 8 in stage two. Finally, guided C2 screw placement was evaluated by reading postoperative computed tomography images and comparing the planned and inserted screw trajectories. RESULTS: There were two cortical breaching screws in stage one and three in stage two, but only the cortical breaching screws in stage one were ranked critical. In stage two, the planned entry points and the transverse angles of the anterior C2 screws could be simulated, whereas the declination angles could not be simulated due to intraoperative blockage of the drill bit and screwdriver by the upper teeth. CONCLUSIONS: It was feasible to use individualized templates to guide transoral C2 screw placement. Thus, these drill templates combined with transoral atlantoaxial reduction plate-IV, may improve the accuracy of transoral C2 screw placement and reduce related neurovascular complications. .
Subject(s)
Adult , Humans , Atlanto-Axial Joint/injuries , Bone Screws , Cervical Vertebrae/surgery , Joint Dislocations/surgery , Orthopedic Procedures/instrumentation , Bone Plates , Cadaver , Equipment Design , Feasibility Studies , Imaging, Three-Dimensional , Internal Fixators , Medical Illustration , Orthopedic Procedures/methods , Reference Values , Reproducibility of Results , Tomography, X-Ray ComputedABSTRACT
As an effective tool to study proteins, nucleic acids, cells and other biological samples, atomic force microscope (AFM) has been widely used in various fields of life science. Biological sample preparation via self-assembly is the precondition of the research. In this paper, common self-assembly methods of biological samples such as proteins, lipid films, DNA and cells for AFM studies are reviewed, and how the samples to be well attached to a substrate using appropriate, nondestructive methods is discussed. The trends towards the development in the future are also looked into.